منابع مشابه
Particulate Naturally Processed Peptides Prime a Cytotoxic Response against Human Melanoma in Vitro1
For an efficient antitumor cytotoxic response, tumor antigcnic peptides need to be presented by professional antigen-presenting cells in associa tion with MHC class I molecules. We established in vitro short-term human (II lines from healthy and melanoma-bearing subjects, using as antigen-presenting cells autologous adherent cells after phagocytosis of latex beads coated with melanoma peptides....
متن کاملIdentification and characterization of novel, naturally processed measles virus class II HLA-DRB1 peptides.
Previously, we identified a naturally processed and presented measles virus (MV) 19-amino-acid peptide, ASDVETAEGGEIHELLRLQ (MV-P), derived from the phosphoprotein and eluted from the human leukocyte antigen (HLA) class II molecule by using mass spectrometry. We report here the identification of a 14-amino-acid peptide, SAGKVSSTLASELG, derived from the MV nucleoprotein (MV-N) bound to HLA-DRB1*...
متن کاملParticulate naturally processed peptides prime a cytotoxic response against human melanoma in vitro.
For an efficient antitumor cytotoxic response, tumor antigenic peptides need to be presented by professional antigen-presenting cells in association with MHC class I molecules. We established in vitro short-term human CTL lines from healthy and melanoma-bearing subjects, using as antigen-presenting cells autologous adherent cells after phagocytosis of latex beads coated with melanoma peptides. ...
متن کاملSpecificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
Naturally processed peptides were acid extracted from immunoaffinity-purified HLA-DR2, DR3, DR4, DR7, and DR8. Using the complementary techniques of mass spectrometry and Edman microsequencing, > 200 unique peptide masses were identified from each allele, ranging from 1,200 to 4,000 daltons (10-34 residues in length), and a total of 201 peptide sequences were obtained. These peptides were deriv...
متن کامل. peptides from c - myc - transfected cells reveal Naturally processed HLA class I bound
Naturally processed peptides, bound to HLA-A2, A68, 540 molecules, were isolated from a c-myctransfected lymphoblastoid B cell lines for sequence analysis. Forty-three sequences of bound peptides could be grouped into three structural motifs. One of the peptide sequences obtained, SLLPAIVEL, was identical to a previously reported peptide bound to HLA-A2.1 and was used for grouping HLA-A2-bound ...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/348195a0